RNA Regulators: Formidable Modulators of Yersinia Virulence

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• 作者：Aaron M. Nuss¹ ; Ann Kathrin Heroven¹ ; Petra Dersch¹ ; ^{petra.dersch@helmholtz-hzi.de}
• 关键词：Yersinia ; regulatory RNAs ; riboswitches ; RNA thermometers ; Csr ; thermosensing ; regulated RNA degradation ; gene regulation ; virulence
• 刊名：Trends in Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：19-34
• 全文大小：2475 K
• 卷排序：25

文摘

A large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host–pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.