Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies
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- 作者：Yu-Shan Tsenga ; 1 ; Kim Van Vlieta ; 2 ; Lavanya Raob ; Robert McKennaa ; Barry J. Byrnec ; Aravind Asokanb ; Mavis Agbandje-McKennaa ; mckenna@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adeno-associated viruses ; AAV8 ; AAV9 ; Anti-AAV capsid antibodies ; Host-immune escape
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：236
- 期：Complete
- 页码：105-110
- 全文大小：811 K
文摘
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A panel of mouse monoclonal antibodies were generated against AAV8 and AAV9.
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The new MAbs recognize conformational epitopes.
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In vitro virus neutralization by new antibodies suggests recognition of functional regions.
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The new MAbs provide tools for characterization of AAV8 and AAV9 variants being developed for improved therapeutic efficacy.