Serum amyloid A1: Structure, function and gene polymorphism
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- 作者：Lei Suna ; Richard D. Yea ; b ; richardye@umac.mo" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; amyloid A ; HDL ; high-density lipoprotein ; OMA ; outer membrane protein A ; PBMC ; peripheral blood mononuclear cells ; rhSAA ; recombinant human serum amyloid A ; SAA ; serum amyloid A ; MAPK ; mitogen-activated protein kinases ; SNP ; single-nucleotide polymorphism ; STAT3 ; Signal transducer and activator of transcription 3 ; ABCA1 ; ATP-binding cassette transporter A1 ; ABCG1 ; ATP-binding cassette transporter G1
- 刊名：Gene
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：583
- 期：1
- 页码：48-57
- 全文大小：833 K
文摘
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SAA1 is a major acute-phase serum amyloid A in humans.
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Polymorphism of the SAA1 gene is associated with disease disposition.
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The use of a chimeric recombinant SAA in some studies has raised concerns.
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SAA1 transgenic and knockout mice have been generated for in vivo studies.
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Recent studies have shown regulatory and homeostatic functions of SAA1.