Platelet-activating factor and hydrogen peroxide exert a dual modulatory effect on the transcription of LXRα and its target genes in human neutrophils
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- 作者：Marí ; a E. Reyes-Quiroza ; 1 ; Gonzalo Albaa ; 1 ; Javier Sá ; enza ; Isabel Genizc ; Juan Jimé ; neza ; José ; Martí ; n-Nietod ; Consuelo Santa-Marí ; ab ; Francisco Sobrinoa ; fsobrino@us.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：LXRα ; liver X receptor ; PAF ; platelet-activating factor ; H2O2 ; hydrogen peroxide ; ABCA1 ; ATP-binding cassette transporter A1 ; ABCG1 ; ATP-binding cassette transporter G1 ; SREBP1c ; sterol regulatory element-binding protein 1c ; NF-κB ; nuclear factor κB ; ROS ; reactive oxygen species ; ERK1/2 ; extracellular signal-regulated kinases 1 and 2 ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DFP ; diisopropyl fluorophosphate ; ATZ ; 3-amino-1
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：357-366
- 全文大小：1248 K
文摘
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Dual effects of H2O2 and PAF on the LXRα pathway and its target genes
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Low but not high doses of H2O2 and PAF induce phosphorylation of NF-κB.
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PAF-induced H2O2 was concentration dependent.