Active membrane cholesterol as a physiological effector
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- 作者：Yvonne Langea ; ylange@rush.edu" class="auth_mail" title="E-mail the corresponding author ; Theodore L. Steckb ; tsteck@bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABCA1 ; ATP-binding cassette transporter A1 ; ABCG1 ; ATP-binding cassette transporter G1 ; CRAC ; cholesterol recognition/interaction amino acid consensus ; ER ; endoplasmic reticulum ; GABA ; γ-amino butyric acid ; GPCR ; G protein-coupled receptors ; HDL ; high-density lipoprotein ; HMGR ; hydroxy-3-methylglutaryl-CoA reductase ; HPCD ; 2-hydroxypropyl-β-cyclodextrin ; MBCD ; methyl-β-cyclodextrin ; NPC1 ; Niemann&ndash ; Pick disease type C1 ; NPC1L1 ; Niemann&ndash ; Pick C1-Like 1 ; NPC2 ; Niemann&ndash ; Pick disease t
- 刊名：Chemistry and Physics of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：199
- 期：Complete
- 页码：74-93
- 全文大小：2161 K
文摘
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Membrane sterols not complexed with polar lipids are “active” (very interactive).
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Active cholesterol is a feedback signal that regulates cellular cholesterol levels.
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Cholesterol interacts with a variety of transporter, channel and receptor proteins.
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The function of several of these proteins responds acutely to active cholesterol.
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Active cholesterol may thus be an important regulator of many cellular processes.