Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC
文摘
New triazine analogs were designed and synthesized. Designed compounds were evaluated for their anti-inflammatory activity. These analogs showed higher COX-2 inhibitory activity. COX-1/COX-2 selectivity index of compounds was determined. Histopathological study for in vivo intake of compounds was run.