- 作者：Ahmed N. Abdelhalim ; Ronald A. Alberico ; Amy L. Barczykowski ; Patricia K. Duffner
- 关键词：Krabbe disease ; MRI ; magnetic resonance imaging ; Krabbe phenotypes ; age-related findings
- 刊名：Pediatric Neurology
- 出版年：February, 2014
- 年：2014
- 卷：50
- 期：2
- 页码：127-134
- 全文大小：1244 K
Background
Initial magnetic resonance imaging studies of individuals with Krabbe disease were analyzed to determine whether the pattern of abnormalities corresponded to the phenotype.Methods
This was a retrospective, nonblinded study. Families/patients diagnosed with Krabbe disease submitted medical records and magnetic resonance imaging discs for central review. Institutional review board approval/informed consents were obtained. Sixty-four magnetic resonance imaging scans were reviewed by two neuroradiologists and a child neurologist according to phenotype: early infantile (onset 0-6聽months)聽=聽39 patients; late infantile (onset 7-12聽months)聽=聽10 patients; later onset (onset 13 months-10 years)聽=聽11 patients; adolescent (onset 11-20聽years)聽=聽one patient; and adult (21聽years or greater)聽=聽three patients. Local interpretations were compared with central review.
Results
Magnetic resonance imaging abnormalities differed among phenotypes. Early infantile patients had a predominance of increased intensity in the dentate/cerebellar white matter as well as changes in the deep cerebral white matter. Later onset patients did not demonstrate involvement in the dentate/cerebellar white matter but had extensive involvement of the deep cerebral white matter, parieto-occipital region, and posterior corpus callosum. Late infantile patients exhibited a mixed pattern; 40% had dentate/cerebellar white matter involvement while all had involvement of the deep cerebral white matter. Adolescent/adult patients demonstrated isolated corticospinal tract involvement. Local and central reviews primarily differed in interpretation of the early infantile phenotype.
Conclusion
Analysis of magnetic resonance imaging in a large cohort of symptomatic patients with Krabbe disease demonstrated imaging abnormalities correspond to specific phenotypes. Knowledge of these patterns along with typical clinical signs/symptoms should promote earlier diagnosis and facilitate treatment.