Endogenous ligands of PPAR-γ reduce the liver injury in haemorrhagic shock

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• 作者：Collin ; Marika ; Abdelrahman ; Maha ; Thiemermann ; Christoph
• 关键词：Shock ; PPAR (peroxisome proliferator-activated receptor) ; GW9662
• 刊名：European Journal of Pharmacology
• 出版年：2004
• 出版时间：February 20, 2004
• 年：2004
• 卷：486
• 期：2
• 页码：233-235
• 全文大小：152 K

文摘

We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-γ antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-γ are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury.