Supercritical (CO2 + ethanol) extraction of bioactives from Citrus aurantium peels.
SFE extraction was optimized using response surface methodology, RSM.
Best RSM work conditions at P = 170 bar; static time = 53 min; QCO2 = 2.9 kg h−1.
Highest osthole yield (%) obtained in less than two hour of extraction period.