Synthesis, structure, DNA/protein binding, and cytotoxic activity of a rhodium(III) complex with 2,6-bis(2-benzimidazolyl)pyridine

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• 作者：Roya Esteghamat-Panah^a ; Hassan Hadadzadeh^a ; ^{hadad@cc.iut.ac.ir} ; Hossein Farrokhpour^a ; Jim Simpson^b ; Amir Abdolmaleki^a ; Fatemeh Abyar^c
• 关键词：Rhodium(III) complex ; 2 ; 6-bis(2-benzimidazolyl)pyridine based ligand ; DNA/protein binding ; Cytotoxicity ; Cancer cells ; Molecular docking
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：958-971
• 全文大小：3763 K
• 卷排序：127

文摘

A new Rh(III) complex was synthesized with 2,6-bis(2-benzimidazolyl)pyridine. The complex shows a groove interaction with DNA. The van der Waals interactions and hydrogen bonds play major roles in the binding of the complex to BSA. The cytotoxicity of the complex against the MCF-7 and HT-29 cell lines is higher than cisplatin. The complex has more interaction energy with DNA and BSA in comparison to the free ligand.