Totally implantable central venous access port infections in patients with digestive cancer: Incidence and risk factors

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• 作者：Abdoulaye Touré ; PharmD ; MSc^a ; ^b ; ^{abdoulayek2002@yahoo.fr} ; Philippe Vanhems ; MD ; PhD^c ; ^d ; Catherine Lombard-Bohas ; MD^e ; Philippe Cassier ; MD^e ; Denis Pé ; ré ; -Vergé ; MD^f ; Jean-Christophe Souquet ; MD ; PhD^f ; René ; Ecochard ; MD ; PhD^g ; Cé ; cile Chambrier ; MD ; PhD^a ; ^b ; ^{cecile.chambrier@chu-lyon.fr}
• 关键词：Microorganism ; Chemotherapy ; Cancer ; Parenteral nutrition
• 刊名：American Journal of Infection Control
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：40
• 期：10
• 页码：935-939
• 全文大小：142 K

文摘

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Background

Central venous access port-related bloodstream infection (CVAP-BSI) is associated with morbidity and mortality in patients with cancer. This study examined the incidence rates and risk factors for CVAP-BSI in adult patients with digestive cancer.

Methods

This prospective observational cohort study was performed from 2007 to 2011 in 2 oncology units of a university hospital. Incidence rate was expressed as number of CVAP-BSI per 1,000 catheter-days. A Cox regression model was used to identify risk factors for CVAP-BSI.

Results

A total of 315 patients were included. CVAP-BSI occurred in 41 patients (13.0 % ). The overall incidence rate was 0.76/1,000 catheter-days. The rate was higher in patients with esophageal cancer (1.28. P?= .05) and pancreatic cancer (1.24; P?= .007). Risk factors independently associated with CVAP-BSI were World Health Organization performance status between 2 and 4, catheter utilization-days in the previous month, pancreatic cancer, and parenteral nutrition. Coagulase-negative Staphylococci and enterobacteria were the main microorganisms isolated.

Conclusions

In adult patients with digestive cancer, pancreatic cancer, cumulative catheter utilization-days, World Health Organization performance status, and parenteral nutrition were identified as independent risk factors for CVAP-BSI. Patients with any of these risk factors could be candidates for preventive strategies.