Flavonoids from Friesodielsia discolor

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• 作者：Uma Prawat ; ^{umaprawat@pkru.ac.th} ; Duangraudee Phupornprasert ; Akkarapol Butsuri ; Abdul-Wahab Salae ; Sompong Boonsri ; Pittaya Tuntiwachwuttikul
• 关键词：Friesodielsia discolor ; Annonaceae ; Flavonoids ; Antimycobacterial ; Antiplasmodial ; Cytotoxicity
• 刊名：Phytochemistry Letters
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：5
• 期：4
• 页码：809-813
• 全文大小：308 K

文摘

Phytochemical investigation of the fresh leaves of Friesodielsia discolor (Craib) D. Das led to the isolation of four new flavonoids, 3¡ä-formyl-2¡ä,4¡ä-dihydroxy-6¡ä-methoxychalcone (1), 8-formyl-7-hydroxy-5-methoxyflavanone (2), 8-formyl-5,7-dihydroxyflavanone (3) and 5,3¡ä-dihydroxy-7-methoxyflavone (6), together with two known compounds, lawinal (4) and tectochrysin (5). The structures of the compounds were elucidated by spectroscopic analysis, mainly 1D and 2D NMR techniques (¹H, ¹³C, COSY, HMQC and HMBC), as well as comparison with literature data. The isolates were tested for antiplasmodial, antimycobacterial and cytotoxic activities. Compounds 1, 2, 5 and 6 exhibited cytotoxicity against human tumor cell lines, KB and MCF-7 with the IC₅₀ values in the range of 3.45-14.82 ¦Ìg/ml. Compounds 1, 2, and 5 also showed significant antiplasmodial activity with respective IC₅₀ values of 2.75, 2.78 and 2.08 ¦Ìg/ml.