Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis

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• 作者：Minah Kim^a ; Kang Ik Kevin Cho^b ; Youngwoo Bryan Yoon^b ; Tae Young Lee^c ; Jun Soo Kwon^a ; ^b ; ^d ; ^{kwonjs@snu.ac.kr}
• 关键词：Clinical high risk for psychosis ; Current source density ; Disconnection syndrome ; Mismatch negativity ; Schizophrenia
• 刊名：Clinical Neurophysiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：128
• 期：2
• 页码：331-339
• 全文大小：1475 K
• 卷排序：128

文摘

Schizophrenia patients and clinical high risk subjects show decreased mismatch negativity (MMN) strength in frontal and temporal cortices. Disconnection between MMN-related brain regions exists even prior to psychosis onset. Aberrant MMN generator activity might be related to schizophrenia pathophysiology.