Aberrant β-catenin expression in urothelial carcinomas in blackfoot disease-endemic areas

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• 作者：Yi-Ting Chen^a ; ^b ; Chun-Chieh Wu^a ; Xuan-Ping Liu^c ; Chee-Yin Chai^a ; ^b ; ^c ; ^{cychai@kmu.edu.tw}
• 关键词：Arsenic ; Blackfoot disease ; E-cadherin ; Urothelial carcinoma ; β-catenin
• 刊名：The Kaohsiung Journal of Medical Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：11-16
• 全文大小：738 K
• 卷排序：33

文摘

Arsenic is a well-known toxic element and carcinogenic agent. The aim of this study was to investigate p63, E-cadherin, and β-catenin proteins in urothelial carcinoma (UC) in both arsenic contaminated areas [so-called blackfoot disease (BFD) area] and non-BFD areas. The expressions of p63, E-cadherin, and β-catenin proteins in 20 UC cases of blackfoot disease and 22 UC cases in non-BFD areas were detected using immunohistochemical methods. The results revealed a high p63 expression in 20 (47.6%) UC cases and high E-cadherin expression in six (14.3%) UC cases. Expressions of p63 and E-cadherin showed no significant correlations with clinicopathologic parameters. However, all 20 BFD cases and 12 of 22 (54.5%) non-BFD cases showed aberrant β-catenin expression. Ten out of 22 (45.5%) non-BFD cases also had normal membranous immunoreactivity. The β-catenin staining pattern significantly differed between cases in endemic and nonendemic areas of BFD (p = 0.001). Tumor sites also significantly correlated with β-catenin expression (p = 0.044). In addition, membranous localization of β-catenin was lower in UC from BFD-endemic areas compared with those from non-BFD endemic areas. In conclusion, it is suggested that relocalization of β-catenin from membrane to cytoplasm may be involved in the tumorigenesis of UC from BFD-endemic areas.