Estimation of the minimum mRNA splicing error rate in vertebrates
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- 作者：A. Skandalis askandalis@brocku.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：mRNA splicing ; Aberrant splice variants ; Mutagenesis ; Vertebrates
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：February-March 2016
- 年：2016
- 卷：784-785
- 期：Complete
- 页码：34-38
- 全文大小：378 K
文摘
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mRNA splicing is ubiquitous in vertebrates but splicing error rate is unknown.
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Frequency of aberrant transcripts varies widely among loci, tissues, and species.
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Several processes contribute to aberrant transcript generation.
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Minimum error rate in vertebrates is ∼0.1% aberrant transcripts per intron.