Role of Bmznf-2, a Bombyx mori CCCH zinc finger gene, in masculinisation and differential splicing of Bmtra-2
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- 作者：Gajula Gopinatha ; gnath@cdfd.org.in" class="auth_mail" title="E-mail the corresponding author ; Kallare P. Arunkumara ; arun@cdfd.org.in" class="auth_mail" title="E-mail the corresponding author ; Kazuei Mitab ; Javaregowda Nagarajua ; &dagger ;
- 关键词：Bombyx mori ; Zinc finger gene ; Femaleness ; Splicing ; Masculinisation ; Doublesex ; Transformer
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：32-44
- 全文大小：3815 K
文摘
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The autosomal zinc finger gene Bmznf-2 induces masculinisation by promoting male type of Bmdsx splicing in B. mori.
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The Bmznf-2 also induces differential splicing of Bmtra-2 gene in BmN cells.
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CCCH motifs of BmZNF-2 protein are essential for the differential splicing of Bmdsx and in the aberrant splicing of Bmtra-2.
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5′UTR mediated suppression is operating over Bmznf-2 transcript, most probably in females.