An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

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• 作者：Joseph L. Bedont¹ ; Tara A. LeGates⁸ ; Ethan Buhr⁹ ; Abhijith Bathini¹ ; Jonathan P. Ling¹ ; ² ; Benjamin Bell³ ; Mark N. Wu¹ ; ³ ; ⁴ ; Philip C. Wong¹ ; ² ; Russell N. Van Gelder⁹ ; Valerie Mongrain¹⁰ ; Samer Hattar¹ ; ⁸ ; ^{samer.hattar@gmail.com} ; Seth Blackshaw¹ ; ⁴ ; ⁵ ; ⁶ ; ⁷ ; ¹¹ ; ^{sblack@jhmi.edu}
• 关键词：SCN ; circadian ; LHX1 ; VIP ; sleep ; light ; temperature ; LPS ; resistance ; transcriptome
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：128-136
• 全文大小：2760 K
• 卷排序：27

文摘

LHX1 controls light control of sleep/wake timing by the SCN independent of VIP. LHX1 controls heat resistance of the SCN and behavioral rhythms independent of VIP. LHX1 regulates SCN-enriched genes through VIP-dependent and independent mechanisms. VIP-independent targets of LHX1 do not regulate SCN core clock amplitude.