Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury
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- 作者：Abhinav Kanwala ; c ; 1 ; Hina L. Nizami1 ; Surekha Mallapudib ; Uday Kumar Putchab ; G. Krishna Mohanc ; Sanjay K. Banerjeea ; 1 ; skbanerjee@thsti.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preconditioning ; Ischemia-reperfusion injury ; Oxidative stress ; SGLT1 ; Phlorizin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：472
- 期：2
- 页码：392-398
- 全文大小：2040 K
文摘
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Ischemic preconditioning induced cardioprotection against ischemic injury.
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SGLT1 expression increased during ischemic preconditioning of the heart.
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Inhibition of SGLT1 by phlorizin abrogated the beneficial effect of ischemic-preconditioning.
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SGLT1 plays a crucial role in ischemic preconditioning-induced cardioprotection.