In this work, we report a unique on-chip approach of cancelling feedthrough applied to a Thin-film Piezoelectric-on-Silicon (TPoS) MEMS resonator fully immersed in deionized (DI) water to enhance the signal-to-background ratio (SBR) in the context of full electrical characterization. We experimentally validate the proposed technique by demonstrating an SBR as high as 25dB despite a reasonably low quality factor (Q) of 162 and high dielectric constant of water from a reference SBR of 3.45dB. The proposed technique employs a pair of differential inputs where one input actuates the device while the other input cancels feedthrough and targets package-level parasitic elements associated with measuring in water. The resulting net feedthrough capacitance is reduced from 185fF to just 2.04fF in DI water. These results are based on a simple practical setup where the fabricated device is interfaced with a customized printed circuit board (PCB) by wire-bonds.