To examine cutaneous 尾-HPV types detected on the surface of EGLs in men and describe their presence prior to EGL development.
A retrospective case series was conducted among 69 men with pathologically confirmed EGLs (n = 72) who participated in the HPV Infection in Men Study. Archived exfoliated cells collected from the surface of each EGL and normal genital skin specimens 6-12 months preceding EGL development were tested for 尾-HPV DNA using a type-specific multiplex genotyping assay.
尾-HPV DNA was detected on 61.1% of all EGLs, with types 38 (16.7%), 5 (15.3%), and 12 (12.5%) most commonly identified. HPV prevalence differed across pathological diagnoses, with the largest number of 尾-HPV types detected on condylomas. Most 尾-HPV types were detected on normal genital skin prior to EGL development, though the prevalence was lower on EGLs compared to preceding normal genital skin.
EGLs and the normal genital skin of men harbor a large number of 尾-HPV types; however, it appears that 尾-HPVs are unrelated to EGL development in men. Despite evidence to support a causal role in skin carcinogenesis at UVR-exposed sites, cutaneous HPV appears unlikely to cause disease at the UVR-unexposed genitals.