Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding
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- 作者：Sheng Sun1 ; 2 ; Le Sun3 ; Xi Zhou1 ; Chuanfen Wu1 ; Ruoning Wang1 ; 5 ; Sue-Hwa Lin2 ; 4 ; Jian Kuang1 ; 2 ; jkuang@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：8 February 2016
- 年：2016
- 卷：36
- 期：3
- 页码：331-343
- 全文大小：4142 K
文摘
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Cytosolic ALIX changes from closed to open conformation during M phase induction
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Phosphorylation of the S718-S721 residues produces an open conformation of ALIX
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S718-S721 phosphorylation allows ALIX to function in cytokinetic abscission
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S718-S721 phosphorylation is required for ALIX to support EIAV budding