Computationally efficient dynamic simulation of cellular kinetics via explicit solution of flux balance analysis: xDFBA modelling and its biochemical process applications
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- 作者：Dong Hwi Jeong cacaca26@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sung Jin Yoo yusungj@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jung Hun Kim acey@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jong Min Lee ; jongmin@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bioreactor ; Kinetic modelling ; Flux balance analysis ; Parametric programming ; Parameter estimation ; Reference tracking
- 刊名：Chemical Engineering Research and Design
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：85-95
- 全文大小：1285 K
文摘
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Existing dynamic flux balance analysis has an embedded linear program.
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Its solution can be integrated with kinetic model by using parametric programming.
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Explicit dynamic flux balance analysis or xDFBA model framework is newly proposed.
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Its applicability is confirmed with several biochemical process examples.