AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
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- 作者：Antero Salminena ; antero.salminen@uef.fi" class="auth_mail" title="E-mail the corresponding author ; Anu Kauppinenb ; Kai Kaarnirantac ; d
- 关键词：ACAT1 ; acetoacetyl-CoA thiolase ; ACC ; acetyl-CoA carboxylase ; AICAR ; 5-aminoimidazole-4-carboxamide ribonucleoside ; AMPK ; AMP-activated protein kinase ; ATAC ; Ada-two-A-containing ; BET ; bromodomains and extra-terminal motif ; BMAL1 ; PAS domain-containing protein 3 ; BRD4 ; bromodomain containing 4 ; CaMKKβ ; Ca2 ; +/calmodulin-dependent protein kinase kinase β ; CoA ; coenzyme A ; CK 1 ; casein kinase 1 ; CLOCK ; clock circadian regulator ; CREB ; cyclic AMP response element binding protein ; CRY ; cryptochr
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：887-895
- 全文大小：497 K
文摘
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AMPK/Snf1 signaling is a critical regulator of energy metabolism in mammals/yeast.
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AMPK can translocate from cytoplasm into nucleus where it regulates transcription.
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AMPK stimulates histone acetylation by exporting histone deacetylases from nuclei.
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AMPK increases acetyl CoA and NAD+ production thus affecting histone acetylation.
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AMPK can control chromatin landscape through the epigenetic regulation.