Classification and structural analyses of mutational landscapes in hemochromatosis factor E protein: A protein defective in the hereditary hemochromatosis
Sequence and structure of HFE were analyzed to find possible mutations. p.Cys282Tyr and p.His63Asp are most prevalent mutations in HFE causing hemochromatosis. MD simulations were performed to check the structure and stability. Several mutations cause decrease in the activity and stability of HFE.