The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers
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- 作者：Robert R. Bowersa ; 1 ; Alexis M. Temkinb ; 1 ; Louis J. Guilletteb ; c ; John E. Baatzc ; d ; Demetri D. Spyropoulosa ; b ; d ; spyropdd@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DWH ; Deepwater Horizon ; CWAF ; Corexit-enhanced Water Accommodated Fraction ; DOSS ; dioctyl sodium sulfosuccinate ; EDCs ; endocrine disrupting chemicals ; RXRα ; retinoid X receptor alpha ; PPARγ ; peroxisome proliferator-activated receptor gamma ; TBT ; tributyltin ; RA ; retinoic acid ; qPCR ; quantitative real-time reverse transcriptase polymerase chain reaction ; MIM ; minimal induction media
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：238
- 期：Complete
- 页码：61-68
- 全文大小：1472 K
文摘
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Endocrine disrupting chemicals (obesogens) may contribute to the obesity epidemic.
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PPARγ and RXRα are master regulators of adipogenesis.
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Span 80 binds to and transactivates RXRα and promotes adipogenesis in vitro.
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Corexit crude oil dispersants contain the putative obesogens DOSS and Span 80.