Impact of repeated asenapine treatment on FosB/ΔFosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat
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- 作者：Zuzana Majercikovaa ; Lubica Horvathovaa ; Jana Osackaa ; Jan Pecenakb ; Alexander Kiss ; Dr. ; Ph.D. ; D. Sci.a ; ueenkiss@savba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asenapine ; Chronic unpredictable variable mild stress (CMS) ; FosB/ΔFosB ; Rat
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：29-37
- 全文大小：3097 K
文摘
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Repeated ASE increased FosB/ΔFosB in striatum and shell of the nucleus accumbens.
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CMS lowered ASE effect on FosB/ΔFosB in striatum and shell of the nucleus accumbens.
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CMS itself did not affect FosB/ΔFosB expression in any of structures investigated.
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Highest FosB/ΔFosB expression was seen in prefrontal cortex and lowest in septum.
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ASE-induced FosB/ΔFosB may take part in brain persisting region-specific changes.