Early antipsychotic exposure affects serotonin and dopamine receptor binding density differently in selected brain loci of male and female juvenile rats
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- 作者：Jiamei Liana ; b ; Bo Pana ; b ; Chao Denga ; b ; chao@uow.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT2AR ; serotonin 5-HT2A receptor ; 5-HT2CR ; serotonin 5-HT2C receptor ; 5-HTT ; serotonin 5-HT transporter ; ANOVA ; analysis of variance ; APDs ; antipsychotic drugs ; Cg ; cingulate cortex ; CPu ; caudate putamen ; D1R ; dopamine D1 receptor ; D2R ; dopamine D2 receptor ; DFC ; dorsolateral frontal cerebral cortex ; DAT ; dopamine transporter ; NAc ; nucleus accumbens ; NAcC ; nucleus accumbens core ; NAcS ; nucleus accumbens shell ; PFC ; prefrontal cortex ; PD ; postnatal day
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：5
- 页码：1028-1035
- 全文大小：1165 K
文摘
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Olanzapine decreased 5-HT2A, 5-HT2C bindings in all frontal brain regions of both male and female juvenile rats.
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Risperidone decreased 5-HT2A, 5-HT2C bindings in the prefrontal cortex.
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Aripiprazole reduced the 5-HT2A bindings in the male PFC, but had no effects on 5-HT2C bindings.
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Early antipsychotic treatment had less effects on dopamine D1/D2 receptor bindings.
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Early antipsychotic treatment caused some gender-dependent changes.