Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats

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• 作者：C. Diepenbroek^a ; ¹ ; M. Rijnsburger^a ; ¹ ; L. Eggels^a ; K.M. van Megen^a ; M.T. Ackermans^c ; E. Fliers^a ; A. Kalsbeek^a ; ^b ; M.J. Serlie^a ; S.E. la Fleur^a ; ^{s.e.lafleur@amc.uva.nl}
• 关键词：ACh ; Acetylcholine ; cNAc ; core region of the nucleus accumbens ; DBS ; deep brain stimulation ; EGP ; endogenous glucose production ; NAc ; nucleus accumbens ; LH ; lateral hypothalamic area ; SSRI ; shell region of the nucleus accumbens ; sNAc ; shell region of the nucleus accumbens ; T2DM ; type 2 diabetes mellitus ; WAT ; white adipose tissue
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：85-90
• 全文大小：1206 K
• 卷排序：637

文摘

Fluoxetine infused in the nucleus accumbens shell (sNAc), increases blood glucose. Fluoxetine’s effects were partly explained by increased glucose production. Effect of fluoxetine in sNAc is independent of glucoregulatory hormones changes. We show first support for a role of the cortico-limbic system in glucose metabolism.