伪-Aminoamides as ligands in Goldberg amidations

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• 作者：Aurpon W. Mitra ; Marvin M. Hansen ; Michael E. Laurila ; Stanley P. Kolis ; Joseph R. Martinelli
• 关键词：Amidation ; Aminoamide ; Cross-coupling ; Cu catalysis ; Acetamide
• 刊名：Tetrahedron Letters
• 出版年：27 November, 2013
• 年：2013
• 卷：54
• 期：48
• 页码：6580-6583
• 全文大小：3476 K

文摘

伪-Aminoamides are shown to be useful as ligands in Goldberg amidations. A number of 伪-aminoamides are examined and the importance of substitution on the 伪-aminoamides is explored. Acetamide is focused on as the nucleophilic coupling partner due to its low cost, stability and convenience as a protecting group. The initial substrate scope for these catalysts is explored and includes electronically activated and deactivated aryl bromides, however o-substituted aryl bromides are problematic.