Global profiling of lysine acetylation in human histoplasmosis pathogen Histoplasma capsulatum
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- 作者：Longxiang Xiea ; 1 ; Wenjie Fangb ; 1 ; Wanyan Denga ; 1 ; Zhaoxiao Yua ; Juan Lib ; Min Chenb ; Wanqing Liaob ; Jianping Xiea ; georgex@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weihua Panb ; panweihua@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lysine acetylation ; Mass spectrometry ; Histoplasma capsulatum ; virulence
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：1-10
- 全文大小：2786 K
文摘
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Our data provides the first global survey of acetylation in Histoplasma capsulatum and we identified 775 acetylation sites on 456 acetylated proteins.
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Acetylated proteins are involved in the regulation of different cellular processes including metabolism and protein synthesis.
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Six types of acetylated peptide sequence motif were revealed from the acetylome.
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Some virulence factors candidates including calmodulin and DnaK are acetylated.