Histone H3 acetylation in the postmortem Parkinson’s disease primary motor cortex
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- 作者：Kibrom G. Gebremedhina ; David J. Rademachera ; b ; drademacher@carthage.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; 6-OHDA ; 6-hydroxydopamine ; AcH3 ; acetylated histone H3 ; AcH3K9 ; acetylated histone H3 lysine 9 ; AcH3K14 ; acetylated histone H3 lysine 14 ; AcH3K18 ; acetylated histone H3 lysine 18 ; AcH3K23 ; acetylated histone H3 lysine 23 ; BDNF ; brain-derived neurotrophic factor ; α-syn ; α-synuclein ; DAergic ; dopaminergic ; GDNF ; glia cell line-derived neurotrophic factor ; HDAI ; histone deacetylase inhibitor ; HDACIs ; histone deacetylase inhibitors ; H3K9 ; histone H
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：3 August 2016
- 年：2016
- 卷：627
- 期：Complete
- 页码：121-125
- 全文大小：693 K
文摘
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Net histone H3 acetylation was increased in the PD primary motor cortex.
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H3K14 and H3K18 acetylation were increased in the PD primary motor cortex.
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H3K9 acetylation was increased in the PD primary motor cortex.
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No between-groups difference in H3K23 acetylation was detected.
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The data suggest enhanced gene transcription in the PD primary motor cortex.