Exercise-induced modulation of histone H4 acetylation status and cytokines levels in patients with schizophrenia

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• 作者：Caroline Lavratti^a ; Gilson Dorneles^b ; Daniela Pochmann^a ; Alessandra Peres^a ; ^b ; André ; ia Bard^c ; Lucas de Lima Schipper^c ; Pedro Dal Lago^d ; Luciane Carniel Wagner^a ; Viviane Rostirola Elsner^a ; ^{vivielsner.fisiologia@gmail.com}
• 关键词：Schizophrenia ; Exercise ; Inflammatory response ; Global histone H4 acetylation levels ; Body mass ; Body mass index
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：84-90
• 全文大小：381 K
• 卷排序：168

文摘

The concurrent exercise protocol reduced body mass and BMI in SZ individuals. The intervention induced short and long-term histone H4 hypoacetylation status. The levels of cortisol and IL-4 remain unchanged after exercise intervention. A remarkable reduction was found in IL-6 levels 60 and 90 days after intervention. Diminished IFN-γ levels were observed in the 90 days period.