The Metabolic Impact on Histone Acetylation and Transcription in Ageing

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• 作者：Shahaf Peleg¹ ; ² ; ^{Shahafpeleg3@googlemail.com" class="auth_mail" title="E-mail the corresponding author} ; Christian Feller³ ; Andreas G. Ladurner¹ ; ⁴ ; ⁵ ; Axel Imhof² ; ⁴ ; ⁵ ; ⁶ ; ^{imhof@lmu.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：aging ; metabolism ; epigenetics ; protein acetylation ; histone acetylation
• 刊名：Trends in Biochemical Sciences
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：41
• 期：8
• 页码：700-711
• 全文大小：2177 K

文摘

Loss of cellular homeostasis during aging results in altered tissue functions and leads to a general decline in fitness and, ultimately, death. As animals age, the control of gene expression, which is orchestrated by multiple epigenetic factors, degenerates. In parallel, metabolic activity and mitochondrial protein acetylation levels also change. These two hallmarks of aging are effectively linked through the accumulating evidence that histone acetylation patterns are susceptible to alterations in key metabolites such as acetyl-CoA and NAD⁺, allowing chromatin to function as a sensor of cellular metabolism. In this review we discuss experimental data supporting these connections and provide a context for the possible medical and physiological relevance.