Analysis of neuronal nicotinic acetylcholine receptor α4β2 activation at the single-channel level
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- 作者：Camila Carignano ; Esteban Pablo Barila ; Guillermo Spitzmaul ; gspitz@criba.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACh ; acetylcholine ; BS ; binding site ; HC ; high-conductance ; HS ; high-sensitivity ; LC ; low-conductance ; LS ; low-sensitivity ; nAChRs ; nicotinic acetylcholine receptors
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：1964-1973
- 全文大小：1488 K
文摘
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Kinetic of nAChRs activation was evaluated at the single-channel level.
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Two channel amplitudes were determined in transfected cells.
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Low-conductance channel has a low activation efficacy.
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Kinetic parameters for the high-conductance channel were obtained.
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The analysis suggests the presence of intermediate states that preclude openings.