Cholinergic activation of the murine trachealis muscle via non-vesicular acetylcholine release involving low-affinity choline transporters
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- 作者：Christina Nassensteina ; christina.nassenstein@anatomie.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Silke Wieganda ; Katrin S. Lipsb ; Guanfeng Lic ; Jochen Kleinc ; Wolfgang Kummera
- 关键词：ACh ; acetylcholine ; AChE ; acetylcholinesterase ; BChE ; butyrylcholinesterase ; ChAT ; choline acetyltransferase ; CHT1 ; choline high affinity transporter ; CTL ; choline-transporter like protein ; EFS ; electrical field stimulation ; HC-3 ; hemicholinium-3 ; VAChT ; vesicular acetylcholine transferase
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：29
- 期：1
- 页码：173-180
- 全文大小：1068 K
文摘
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Esterase inhibition causes cholinergic tracheal constriction of the murine trachea without further stimulation.
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Non-quantally released acetylcholine is physiologically cleaved by AChE in the airways.
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Cholinergic tracheal constriction induced by esterase inhibition involves low-affinity choline transporters.