Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2′-N-acetyltransferase in Mycobacterium tuberculosis
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- 作者：Amudha Prabua ; Sameer Hassanb ; Prabuseenivasana ; A.S. Shainabaa ; L.E. Hannab ; Vanaja Kumarc ; vanaja_kumar51@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; Antimycobacterial activity ; Andrographolide ; Drug target ; Docking ; Molecular simulation
- 刊名：Journal of Molecular Graphics and Modelling
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：61
- 期：Complete
- 页码：133-140
- 全文大小：1657 K
文摘
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The Anti-tuberculosis activity of Andrographis paniculata was screened using Luciferase Reporter Phage Assay (LRP).
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Based on the bioassay guided fractionation, Andrographolide has been identified as an active molecule.
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The probable drug target for Andrographolide was identified by using docking analysis.
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Molecular simulation was performed to refine the target—drug complex.