Thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: A causal relationship?

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• 作者：Achilleas Attilakos ; Anastasia Garoufi ; Konstantinos Voudris ; Sotiria Mastroyianni ; Aspasia Fotinou ; Dimitrios T. Papadimitriou ; Nikolaos Gavalakis ; Alexia Prassouli ; Eustathia Katsarou
• 关键词：Thyroid ; Carbamazepine monotherapy ; Children ; Epilepsy ; Low-density lipoprotein cholesterol
• 刊名：European Journal of Paediatric Neurology
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：11
• 期：6
• 页码：358-361
• 全文大小：198 K

文摘

Lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. The aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine (CBZ) monotherapy.

Materials and methods

Thyroid function was evaluated in 18 epileptic children, previously reported with CBZ-induced changes in serum lipid profile, before and at 6, 12 and 24 months of CBZ monotherapy.

Results

All children had normal thyroid function before the initiation of CBZ treatment. During CBZ therapy thyroid dysfunction, with increased thyrotropin (TSH) and decreased thyroxine (T4), free thyroxine (FT4) and triiodothyronine (T3) was found, while, significant association was revealed between serum low-density lipoprotein cholesterol (LDL-C) and TSH levels at 6 (r=0.469; p=0.043) and 12 (r=0.730; p=0.001) months of treatment.

Conclusion

Lipid abnormalities may be associated with thyroid hormone disturbance in children treated with CBZ monotherapy. Since thyroid dysfunction and hypercholesterolemia are both associated with a higher atherosclerotic risk special attention and further studies are needed in epileptic patients treated with CBZ monotherapy.