Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130
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- 作者：Justin Joachim1 ; Harold B.J. Jefferies1 ; Minoo Razi1 ; David Frith2 ; Ambrosius P. Snijders2 ; Probir Chakravarty3 ; Delphine Judith1 ; Sharon A. Tooze1 ; sharon.tooze@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：60
- 期：6
- 页码：899-913
- 全文大小：6109 K
文摘
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WAC is required for ULK activation and autophagy and interacts with GM130
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WAC suppresses GM130 binding to GABARAP and activates autophagy
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GABARAP traffics from the pericentriolar matrix to forming autophagosomes
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WAC controls the non-hierarchical activation of ULK complex by centrosomal GABARAP