miRNA Biogenesis: A Dynamic Pathway

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• 作者：Natalia P. Achkar¹ ; ² ; Damiá ; n A. Cambiagno¹ ; ² ; Pablo A. Manavella¹ ; ^{pablomanavella@ial.santafe-conicet.gov.ar}
• 关键词：microRNA ; miRNA biogenesis ; gene silencing ; small RNA ; splicing.
• 刊名：Trends in Plant Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：21
• 期：12
• 页码：1034-1044
• 全文大小：1816 K
• 卷排序：21

文摘

MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.