刊名:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
出版年:2017
出版时间:January 2017
年:2017
卷:1862
期:1
页码:39-48
全文大小:927 K
卷排序:1862
文摘
Eukaryotic mitochondria have a full set of discrete enzymes for de novo synthesis of fatty acids. Mitochondrial fatty acid synthesis proceeds in an ACP-dependent manner. Failure leads to respiratory deficiency in yeast and embryonic lethality in mammals. Lipoic acid metabolism and mitochondrial fatty acid synthesis are tightly interlinked. Human mitochondrial ketoreductase (KAR) of mitochondrial fatty acid synthesis links this process to mitochondrial β-oxidation.