文摘
HAP1 is abundantly expressed in spinal neurons of the somatosensory, viscerosensory and autonomic regions. More than 80% of neurons expressed both HAP1 and androgen receptor (AR) in the dorsal horn and around the central canal. HAP1 was completely lacking in the spinal motoneurons with or without AR expression. Due to lack of putative HAP1 protectivity, motoneurons might be more vulnerable to stresses in neurodegenerative diseases.