N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan
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- 作者：Yousuke Kounoa ; d ; 1 ; Makoto Anrakua ; b ; 1 ; Keishi Yamasakia ; b ; Yoshiro Okayamad ; Daisuke Ioharaa ; Hedeaki Nakamurac ; Toru Maruyamac ; Fumitoshi Hirayamaa ; b ; Ulrich Kragh-Hansene ; Masaki Otagiria ; b ; otagirim@pH.sojo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSA ; human serum albumin ; rHSA ; recombinant HSA ; N-AcMet ; N-acetyl-L-methionine ; N-AcTrp ; N-acetyl-L-tryptophan ; Oct ; octanoate ; ROS ; reactive oxygen species ; CT ; chloramine-T ; DSC ; differential scanning calorimetry ; CD ; circular dichroism
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：266-274
- 全文大小：675 K
文摘
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N-acetyl-L-methionine (N-AcMet) was found to be a superior ROS scavenger.
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N-AcMet is an efficient stabilizer of albumin structure exposed to ROS.
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The presence of N-AcMet improves the pharmacokinetics of ROS-exposed albumin.
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N-AcMet should replace N-acetyl-
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N-AcMet is a new and safe additive for recombinant and serum-derived albumin forms.