Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors

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• 作者：Shrinivas D. Joshi^a ; ^{shrinivasdj@rediffmail.com} ; Sheshagiri R. Dixit^a ; Venkatarao H. Kulkarni^a ; Christian Lherbet^b ; ^c ; Mallikarjuna N. Nadagouda^a ; Tejraj M. Aminabhavi^a
• 关键词：GALAHAD ; Pharmacophore hypothesis ; Surflex docking ; Pyrrolyl benzohydrazide derivatives ; Antitubercular activity ; Enzyme inhibition studies
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：286-297
• 全文大小：2568 K
• 卷排序：126

文摘

Pharmacophore mapping was carried out using GALAHAD approach on a series of pyrrolyl benzohydrazide derivatives. Synthesis of a range of pyrrolyl benzamide derivatives described. Surflex docking studies was carried out to understand the binding affinity of the compounds. Inhibitors were active against Mycobacterium tuberculosis, Staphylococcus aureus, Eschrichia coli, Cell-line (A549) and InhA.