Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction
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- 作者：Juan-Juan Shenga ; Han-Zhong Fenga ; Jose R. Pintob ; Hongguang Weia ; J.-P. Jina ; jjin@med.wayne.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BSA ; bovine serum albumin ; CON ; control group ; cTnC ; cardiac troponin C ; cTnI ; cardiac troponin I ; cTnT ; cardiac troponin T ; cTnI-ND ; N-terminal truncated cardiac troponin I ; cTnT-ΔE7 ; exon 7-deleted cardiac troponin T ; cTnT-ND ; N-terminal truncated cardiac troponin T ; DHF ; diastolic heart failure ; ; ± ; ; dP/dt ; contractile and relaxation velocities ; EF ; ejection fraction ; FBS ; fetal bovine serum ; HFpEF ; heart failure with preserved ejection fraction ; LVPmax ; left ventricular maximu
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：218-229
- 全文大小：2012 K
文摘
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Desmin and α-actinin were increased in hearts with diastolic dysfunction but not hearts with systolic dysfunction.
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The increased desmin and α-actinin are mainly in myofibrils at the Z-disks.
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TAC induced desmin and α-actinin in occult diastolic heart failure but not in wild type or mildly systolic dysfunction heart.
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The data demonstrate an early response specifically to diastolic heart failure, indicating a function of the Z-disk.