Insecticide sensitivity of native chloride and sodium channels in a mosquito cell line
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- 作者：Lacey J. Jensona ; b ; Troy D. Andersonb ; Jeffrey R. Bloomquista ; jbquist@epi.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CACC ; calcium-activated chloride channel ; CI ; 95% confidence intervals ; DIDS ; 4 ; 4&prime ; -diisothiocyano-2 ; 2&prime ; -stilbenedisulfonic acid ; EC50 ; effective concentration at half maximal effect ; IC50 ; inhibitory concentration at 50% of initial effect ; FNV ; fenvalerate ; GABA ; gamma-aminobutyric acid ; TTX ; tetrodotoxin ; VSCC ; voltage-sensitive chloride channel ; VTD ; veratridine
- 刊名：Pesticide Biochemistry and Physiology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：59-64
- 全文大小：731 K
文摘
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Sua1B cell growth was inhibited by insecticides.
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Cl− currents were enhanced in the presence of lindane in a Ca++ dependent manner.
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DIDS blocked Cl− currents in most cells, but some were insensitive.
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Type 2, but not type 1 pyrethroids also significantly reduced Cl− currents.
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A type of “electrically silent” Na+ channels may exist in Sua1B cells.