We examined voltage-gated Ca2 + channels in cultured motoneurons in G93A-SOD1 mice.
G93A-SOD1 motoneurons exhibit increased high voltage activated Ca2 + currents.
G93A-SOD1 motoneurons also display altered persistent Ca2 + currents.
G93A-SOD1 motoneurons have altered Ca2 + channel mRNA expression and immunoreactivity.
Voltage-gated Ca2 + channels might contribute to ALS pathogenesis.