Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels
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- 作者：Isabella Salzer1 ; Enkhbileg Gantumur1 ; Arsalan Yousuf ; Stefan Boehm ; stefan.boehm@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dorsal root ganglion neurons ; 5HT2 receptors ; TRPV1 channels ; Ca2+-activated chloride channels ; TTX-resistant Na+ channels ; Kv7 K+ channels
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：277-286
- 全文大小：1466 K
文摘
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5HT sensitizes TRPV1 channels in DRG neurons via 5HT2A, 5HT2B, as well as 5HT2C receptors.
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5HT triggers inward currents through Ca2+-activated Cl- channels of DRG neurons via 5HT2C, but not 5HT2A or 2B receptors.
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5HT causes an increase in action potential firing in DRG neurons that involves TRPV1 and Ca2+-activated Cl− channels.
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The increase in action potential firing in DRG neurons caused by 5HT involves 5HT2C, but not 5HT2A or 2B receptors.
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5HT2C rather than 5HT2A or 2B receptors mediate the excitation of DRG neurons by 5HT.