Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys

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• 作者：Norikazu Kiguchi^a ; ^d ; ¹ ; Huiping Ding^a ; ¹ ; Christopher M. Peters^b ; Nancy D. Kock^c ; Shiroh Kishioka^d ; J. Mark Cline^c ; Janice D. Wagner^c ; Mei-Chuan Ko^a ; ^{mko@wakehealth.edu}
• 关键词：Astrocytes ; Microglia ; Chemokines ; Opioids ; Neuroinflammation ; Chronic pain ; Spinal cord ; Thalamus ; Diabetes ; Macaques
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：274-283
• 全文大小：2781 K
• 卷排序：1863

文摘

Astrocytes and microglia are activated in the spinal dorsal horn (SDH) of diabetic monkeys. Multiple chemokine ligands and receptors (e.g., CCL3-CCR1/5) are simultaneously up-regulated in the SDH of diabetic monkeys. Opioid receptors, MOP, DOP, KOP, but not NOP receptors, are down-regulated in the SDH of diabetic monkeys. Ligand-receptor systems as pain modulators in the SDH are more susceptible to changes than in the thalamus of primates. Neuroinflammation seems to be permanent in the spinal cord of type 2 diabetic monkeys.