Goji fruit (Lycium barbarum) protects sciatic nerve function against crush injury in a model of diabetic stress
详细信息 查看全文
- 作者：K.V. Simonyan ; karensimonyan86@gmail.com" class="auth_mail" title="E-mail the corresponding author ; L.G. Avetisyan ; V.A. Chavushyan
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; CNS ; central nervous system ; DNA ; deoxyribonucleic acid ; GABA ; gamma-aminobutyric acid ; GLUT4 ; glucose transporter type 4 ; MNCV ; motor nervous conduction velocity ; HFS ; high frequency stimulation ; ITS ; intermediate toe-spread ; JNK ; jun amino-terminal kinase ; KCC2 ; potassium-chloride transporter member 5 ; LB ; lycium barbarum ; LBP ; lycium barbarum polysaccharide ; NF-κB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; NMDA
- 刊名：Pathophysiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：23
- 期：3
- 页码：169-179
- 全文大小：3060 K
文摘
Excess fructose consumption causes changes in functioning of the central and peripheral nervous systems, which increase the vulnerability of peripheral nerves to traumatic injury. The aim of this study was to evaluate the electrophysiological parameters of responses of motoneurons of the spinal cord at high-frequency stimulation of the distal part of the injured sciatic nerve in a model of diabetic stress under action of Lycium barbarum (LB). Male albino rats were given with drinking water with 50% concentration of dietary fructose for 6 weeks. Starting on the 7th week a crush injury of the left sciatic nerve was carried out. Some of the animals received fructose post-injury for 3 weeks and some of the animals received fructose + dry LB fruits for 3 weeks. In the fructose + crush + LВ group a relatively proportional division of tetanic and posttetanic potentiation and depression in responses of ipsilateral and contralateral motoneurons was observed, which would suggest the modulatory role of LB in short-term synaptic plasticity formation. Generally, LB fruit is able to modulate central nervous system reorganization, amplifying positive adaptive changes that improve functional recovery and promote selective target reinnervation in high fructose-diet rats with sciatic nerve crush-injury.