The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target
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- 作者：Jin Chu ; Domenico Praticò ; ; praticod@temple.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; 5-lipoxygenase ; Amyloid beta ; γ-Secretase ; γ-Secretase activating protein
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：126
- 期：part_P2
- 页码：207-212
- 全文大小：1078 K
文摘
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5Lipoxygenase is upregulated in brain aging and Alzheimer’s disease.
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5Lipoxygenase acts as an endogenous modulator of Aβ formation in vitro and in vivo.
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5Lipoxygenase modulates the four components of the γ-secretase complex at the transcription levels without affecting Notch signaling.
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5Lipoxygenase has a pleiotropic effect on the entire spectrum of the Alzheimer’s disease phenotype.
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5Lipoxygenase is a viable therapeutic target for Alzheimer’s disease.